Computer Models for Vaccines

 Much more in Nature Mag, linked to below.

Could Computer Models Be the Key to Better COVID Vaccines?

In Nature, Elie Dolgin, April 5, 2022

Scientists have been developing mathematical and computational models over the past several years to supplement dosage decision-making for vaccine tests, and some advocates suggest their use would have made COVID vaccines more effective. Previous experience and animal testing typically inform dose selection for experimental vaccines like the COVID-19 vaccine, yielding a range of dosages. Vaccine-dose modeling starts with researchers feeding immune-response results from animal experiments into equations to generate a predicted dose-response curve; this is scaled to humans using clinical data from a smaller dose number, often from historical research on similar vaccines. The result is expected "best" dosages for human testing, which can be further refined as more data becomes available.   .... '