Software Assembles Complete Genome Sequences On-Demand
National Human Genome Research Institute
Anna Rogers, February 16, 2023
The Verkko software created by U.S. National Institutes of Health (NIH) researchers can construct complete genome sequences from diverse species. Sergey Koren at NIH's National Human Genome Research Institute (NHGRI) said Verkko automates the process used in last year's assembly of the first gapless human genome sequence by the Telomere-to-Telomere consortium. The consortium took years to manually assemble the remaining 8% to 10% of the sequence, which Verkko can accomplish in days. The software pieces together small fragments to produce partial components, then compares the constructed regions with larger fragments; the latter become a scaffold for arranging the more detailed regions into a complete sequence. NHGRI's Adam Phillippy said, "Verkko can democratize generating gapless genome sequences," and "will make assembling complete genome sequences as affordable and routine as possible."
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