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Wednesday, August 12, 2020

Summit Supercomputing Cracking Covids Code

Saw the supercomputing systems tested with combinatorial problems.  Will this be a coup for understanding Covid?

Has Summit Cracked Covid's Code?
IEEE Spectrum
Mark Anderson
August 2, 2020

Researchers at the U.S. Department of Energy’s Oak Ridge National Laboratory may have uncovered how the novel coronavirus causes disease, as well as identifying new potential therapies. The supercomputer-powered genetic study of Covid-19 patients found a common pattern of gene activity in the lungs of symptomatic patients. Lung fluid samples from Covid-19 patients found an over-expression of genes that produce bradykinin (a compound that controls blood pressure) and an under-expression of genes that would inhibit or break down the compound. Oak Ridge's Summit and Rhea supercomputers also found an increase in hyaluronic acid in the lung due to down-regulated genes that might otherwise have kept levels of this gelatin-like substance in check. The researchers identified 10 therapies developed for other conditions that could potentially address these issues. ... "

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