Cellular 'Command Sentences'.
News-Medical Life Sciences, Emily Henderson, December 8, 2022
Researchers at the University of California, San Francisco (UCSF) and IBM Research have compiled a virtual molecular database of thousands of cellular "command sentences." The researchers based the sentences on combinations of molecular "words" that directed engineered CAR-T immune cells to hunt down and destroy cancer cells. USCF's Wendell Lim and Kyle Daniels concentrated on the part of a receptor within the cell containing amino acid strings, each of which functions as a command "word." Stringing the words into a "sentence" influences the commands the cell will follow. Daniels and the IBM researchers applied novel machine learning to the data to produce new receptor sentences to boost the CART-T cells' effectiveness.
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