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Sunday, December 19, 2021

Discovering effective Drug Therapy

 Chemical compound discovery and application for drug therapy. 

Scientists Can Efficiently Screen Billions of Chemical Compounds to Find Effective Drug Therapies

USC Dornsife College of Letters, Arts, and Sciences

Darrin S. Joy, December 15, 2021

An international team of researchers led by the University of Southern California Dornsife College of Letters, Arts, and Sciences has devised a method of identifying effective drugs among billions of chemical compounds, more quickly and cost-efficiently than current methods. The V-SYNTHES (Virtual Synthon Hierarchical Enumeration Screening) method works directly with synthons, the virtual chemical building blocks of the REAL (readily available for synthesis) Space library, to identify the best molecules to match up with specific protein targets. V-SYNTHES was able to mine synthon libraries to identify drug-like molecules that could selectively target cannabinoid receptors more than 5,000 times faster than standard algorithms. ... ' 


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