Tuberculosis Vaccine

 An example of pharma design

Computational Models Move Researchers Closer to Tuberculosis Vaccine

UC San Diego News Center,  Kimberly Mann Bruch, January 13, 2022

The University of Michigan's Denise Kirschner and colleagues are using supercomputers at the San Diego Supercomputer Center at the University of California, San Diego (UCSD) to investigate tuberculosis (TB), as a means of informing vaccine design. Kirschner said the work has shed light on the role of neutrophil cells in the immune response to TB infection. Predictive models using UCSD's Expanse supercomputer enabled the researchers to use images of neutrophils within TB granuloma to produce high-resolution models showing cells reacting to the disease. Said Kirschner, "Our computational approach and results from our recent study have helped narrow this concerning 'vaccine design space'—getting us closer to a globally effective vaccine."